Gene to reduce inflammation after a stroke

When a person suffers a stroke, they become vulnerable to an inflammation. This increases the swelling around the injury and adds to several other complications. In the latest issue of Cell Reports, a journal based on life sciences spectrum, researchers at University of Southern California discovered that the involvement of TRIM9 gene can reduce inflammation in the brain. It also highlighted, that good quantity of this gene works miracles on the injured brain. The study reconfirms that not all inflammation in the brain are bad, only the ones that last long, makes the brain’s blood vessels more porous, which allows white blood cells to enter tissue.

Through a lab model of stroke, researchers found that brains deficient of the key gene were more prone to extensive swelling which followed after a stroke. With an experiment they confirmed the hypothetical assumption.  Scientists used a harmless virus to carry a dose of the gene directly into TRIM9-lacking brains. The results showed that the swelling decreased dramatically and also improved recovery.

However, researchers confirm that this wouldn’t be an instant go-to treatment for a stroke, since the process is slow and a stroke needs to be tended urgently. Scientists are investigating ways to chemically activate the gene TRIM9 after a stroke.