Pressure Bio Sciences and the Steinbeis Centre jointly puts efforts for the development of innovative way for the Optimization of Disease-Fighting Antibodies

The collaborative program will be directed by Dr. Michael Przybylski, who’s the Analytical Chemistry and Biochemistry professor as well as being the Director of The Steinbeis Centre, explained this platform by saying: “The high-quality digestion of proteins is an essential initial step in the discovery, analysis, and characterization of potential therapeutic proteins. In the past, we have not been fully satisfied with the results achieved when using traditional protein digestion procedures and instrumentation. However, with PBI’s proprietary PCT platform, we now achieve high quality and reproducible digestion of proteins. Consequently, we believe that PCT, in combination with our innovative PROTEX-MS system, could more rapidly lead to the discovery and development of biopharmaceutical treatments for a large number of diseases, resulting in substantial improvements in patient care and outcomes.”

Chief Science Officer at PBI, Dr. Alexander Lazarev stated that: “We believe the PCT-PROTEX-MS platform being developed will offer the global research community a powerful new laboratory tool for the rapid and sensitive digestion of protein and peptide antigens followed by measurement of binding affinity (strength) and identification of epitopes captured on immobilized antibodies.”

Dr. Alexander Lazarev further added: “Furthermore, the potential of this new platform in the rapid discovery of new targeted therapeutics and improvement of existing treatments tailored specifically to individual patients and their conditions offers great promise for a wide range of diseases and conditions, including cancer, arthritis, Crohn’s disease, and transplant rejection.”

The Chief Commercial Officer at PBO, Dr. Bradford A Young said: “We are delighted to be collaborating with a research team of such global stature as The Steinbeis Centre to develop a new platform technology for the characterization of binding sites on antibodies and the potential development of new and/or better protein therapeutics. This work has very important clinical applications, as it may help to develop more effective protein drugs with reduced side-effects in cancer, autoimmune, neurodegenerative, and other critical diseases and conditions. We are honored that Dr. Przybylski and his team have incorporated our proprietary PCT platform as a critical component of this innovative solution. The results of this collaboration will provide PBI with another valuable and broad application area for our Barocycler instruments, and we anticipate this new instrument system will be of great interest to both current and future customers in the monoclonal antibody therapeutics market, expected to reach $218.97 billion by the end of 2023 (Zion Market Research, 2018).”